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Cytogenetics

Cytogenetic is a branch of genetics which deals with the study of chromosomes.

The only reliable method of diagnosing chromosomal diseases is cytogenetic analysis of the karyotype.

Cytogenetic involves the study of human chromosomes in health and disease. Chromosomal studies are an important laboratory diagnostic procedure in prenatal diagnosis, in certain patients with mental retardation and multiple birth defects, in patients with abnormal sexual development, and in some cases of infertility or multiple miscarriages. Cytogenetic analysis is also useful in the diagnosis and prognosis of patients with malignancies and hematologic disorders.

A much higher incidence of chromosomal disease is seen in early gestation. Approximately half of the human fetuses that are spontaneously aborted during the first trimester are chromosomally abnormal, reflecting chromosomal disorders severe enough to disrupt prenatal development.

Medicogenetic consultation is an important preventive measure, since it detects potential parents with a high risk of producing an affected infant. Intrauterine diagnosis of the fetus’s chromosome set by means of amniocentesis supplements medicogenetic consultation in predicting the outcome of pregnancy in families with the increased risk of producing an infant with a chromosomal disease.

Although chromosomal abnormalities cannot be corrected, some birth defects can sometimes be prevented (for example, taking folate [folic acid] to prevent neural tube defects or screening parents for carrier status of certain genetic abnormalities).

In addition, many human malignant tumors exhibit abnormal chromosomal segregation at cell division. It is believed that these anomalies play a role in tumorigenesis by increasing the rate of chromosome mutations. An elevated frequency of structural chromosome aberrations could be directly caused by an abnormally high incidence of DNA double-strand breaks. Chromosomal breakage can result in a number of different structural rearrangements, some of which give rise to abnormalities of chromosomal segregation at mitosis. Karyotype analysis of malignant tissues helps to diagnose various hematological conditions as well as solid tumors.

For hematologists, Oncologists, Obstrastitians, IVF specialists, Pediatrician, Endocrinologists and neurophysicians Unipath specialty laboratory provide a wide menu in genetic testing to help the patients suffering from leukemia, solid tumors, recurrent abortions and bad obstratic history, children with developmental delay, growth retardation, sex chromosomal abnormalities and mental retardation.

Tests done at Unipath cytogenetics are:

  • Karyotype (bone marrow, blood, amniotic fluid, chorionic villus biopsy, abortus tissue)
  • FISH for hematological malignancies, Solid tumor (Her2 neu gene amplification, ALK gene rearrangements), microdeletion syndromes (Di George syndrome, Prader Willi syndrome) and chimerisum studies.
  • Stress cytogenetic for patients with Fanconi anemia

Our aims is to unlock genetic changes behind disorders

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102, 1st Floor, Sanoma Plaza, Opp. Parimal Garden, Besides JMC House, Ellisbridge, Ahmedabad - 380006.

Mobile :  +91 95588 00100
Telephone :  +91 (79) 2646 8485
Freephone :  +91 (79) 400 22 800
Fax :  +91 (79) 400 22 804

E-mail :  info@unipath.in
Web :  www.unipath.in